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Unlike traditional antidiabetic drugs, GLP-1 agonists act on the brains appetite centers, leading to: Reduced hunger Smaller portion sizes Longer feeling of fullness GLP-1 Drugs15361024 256 KB Do you think GLP-1 drugs will become first-line therapy for obesity in the future or should lifestyle intervention always come first

The cardiovascular, MASH, and sleep-apnea indications remain covered where applicable even where obesity coverage was removed

Abbreviations DPP-4: Dipeptidylpeptidase-4 GIP: Glucose-dependent insulinotropic polypeptide GLP-1: Glucagon-like peptide-1 HbA1C: Hemoglobin A1C HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol T2DM: Type 2 diabetes mellitus References Elrick H, Stimmler L, Hlad CJ, Arai Y