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To validate extraction protocol of all six metabolites from whole blood we used spiking approach

However, not all studies agree

3.8 Risk and bias assessment Based on the Cochrane risk assessment tool, 3 (23%) studies did not mention the random sequence generation method and 4 (31%) did not mention the allocation concealment

Real-world health economic data shows that bariatric surgery leads to approximately 18% lower total medical costs over a two-year period compared to prescription drugs, while also achieving superior metabolic improvements