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Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult

In contrast, during molecular dynamics simulations, the spatial orientation of Arbutin in the Arbutin_b conformation shows noticeable changes compared to its docked structure, which may be attributed to the limited space within the binuclear copper active site that constrains the positioning of the pyranosyl glucose moiety (Fig