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11 Women at high risk of or with known vitamin B 12 deficiency should supplement with vitamin B 12 while pregnant or breastfeeding

Eventually, this results in chronically insufficient GSH levels to neutralize the ROS, leading to oxidative stress that damages lens proteins

Together with the observation that CNS myelin appears to be a major target, this spurred development of various animal models, with the experimental autoimmune encephalomyelitis (EAE) mouse model being the most popular (Baxter, 2007)