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furthermore, phlorizin (the parent compound from which currently marketed SGLT2 inhibitors are derived) is able to inhibit SGLT3 [158] Although few studies have assessed the effects of SGLT2 inhibitors in preclinical models, one recent study has shown that canagliflozin reduces inflammatory cytokine concentrations in skeletal muscle and improves skeletal muscle contractile force in an obese mouse model [159]
Addressing recent docking challenges: a hybrid strategy to integrate template-based and free protein-protein docking
A pooled analysis of SUSTAIN trials found that semaglutide 1 mg reduced triglycerides by 12.4% and total cholesterol by 4.6% from baseline, independent of background statin use [10]
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