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Type 2 diabetes improves dramatically through two pathways: weight loss (reduces insulin resistance) and direct glucose-lowering effects

The first author (VD) independently screened through the titles and abstracts and brought up any eligibility concerns with the last author (FV)

Genetic variants in the GLP1R (rs6923761), GIPR (rs1800437), and FTO (rs9939609) genes affect receptor density and signaling strength, meaning some people respond robustly to tirzepatide while others require higher doses or respond more slowly