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Since levothyroxine requires an acidic gastric environment for optimal dissolution and absorption, and its absorption can be affected by the rate of gastric emptying, patients may experience variations in thyroid hormone levels when starting semaglutide therapy

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While significant adverse effects on liver function haven't been widely reported in initial studies, it's a critical area for ongoing scrutiny

If you're taking antibiotics such as chloramphenicol, colchicine, folic acid, methotrexate, and para-aminosalicylic acid, your doctor may have to monitor your condition for any possible side effects