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Cell-line selectivity improves the predictive power of pharmacogenomic analyses and helps identify nadph as biomarker for ferroptosis sensitivity

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However, it is important to note that scRNA-seq has limited sensitivity for detecting lowly expressed genes, which may lead to an underestimation of the presence or variability of certain channels and receptors in the dataset [44]

The first involves the interaction between one molecule of H 2 O 2 and CAT which leads to the production of Compound I, in which the heme group is oxidized to oxyferryl species [45, 50, 52]