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Neuropharmacology 2008

It has been demonstrated that WECP treatment activated the phosphorylation of Akt and glycogen synthase kinase-3-beta (GSK3), promoted -Catenin and Wnt10b accumulation, and upregulated the expression of lymphoid enhancer-binding factor 1 (LEF1), vascular endothelial growth factor (VEGF), and insulin-like growth factor 1 (IGF1)

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Additionally, the diabetic kidney has increased oxygen demand due to increased sodium reabsorption and (single-nephron) hyperfiltration via increased Na + , K + ATPase activity at the basolateral surface of the tubules [13]