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Semaglutide is FDA-approved for adolescents 12 and older for obesity, and tirzepatide is approved for adolescents 10 and older for Type 2 diabetes

For GLP-1, the review confirmed insulinotropic effects on -cells during hyperglycaemia, glucagonostatic effects on -cells during hyperglycaemia (indirect, via somatostatin and insulin), gastric emptying delay, CNS appetite suppression, and indirect promotion of lipolysis via increased sympathetic activity

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The most successful results are seen in patients who are fully committed to a comprehensive weight management program