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However, the overexpression of des-acyl ghrelin in a transgenic mouse model results in a small phenotype, associated with a reduction of food intake and body fat mass, reduced IGF-1 plasma levels without significant changes in circulating GH and also higher des-acyl ghrelin with no change in total ghrelin plasma levels (Ariyasu et al., in vivo and in vitro (Broglio et al., 2004b

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