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SOURCE: OMZO Source: OMZO
The insufficient in vivo studies on semaglutide and limited in vitro research raise concerns about the imperative for more comprehensive investigations into its effects
Also expect changes in regulations to delay or change priorities
A study on whether and how the activation of GLP-1R affects proliferation and apoptosis of human pancreatic cancer cells has demonstrated that GLP-1RAs might activate cAMP in a GLP-1R-dependent manner, subsequently inhibiting the AKT and ERK1/2 signaling pathways, hence inhibiting the growth of transplanted tumors in vivo , as well as inducing apoptosis and inhibiting the proliferation of a human pancreatic cancer cell line in vitro ( 225)
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