Remarkably, NAD + depletion has been identified as a characteristic feature of MASLD in experimental animals [78, 79], indicating that this molecule could serve as a potential therapeutic target for protecting against hepatic steatosis and further advanced stages such as MASH
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In white adipose tissue, blocking NNMT elevated resting calorie burn, decreased adiposity, and improved insulin sensitivity in rodent models, independent of diet or activity changes (Kraus et al., Nature Medicine )