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Another found semaglutide is effective in reducing alcohol intake and modulating binge-like alcohol drinking in mice, while a third study examined how lab mice taking different GLP-1 medications can more successfully resist cocaine

Peng Z, Sun Y, Lv X, Zhang H, Liu C, Dai S

It also promoted the expression of Arg-1, IL-10, and TGF-, inhibiting ferroptosis and inducing BV2 cell polarization toward the M2 phenotype, thereby mitigating BV2 cell injury

Its unclear how such a treatment would react with adenosines immunostimulatory, primarily anti-inflammatory, effects in distinct immune cell types, 152 or how elevated DPP4 activity and prolonged subclinical inflammation in obesity-induced MS would impact the therapeutic outcome