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N Engl J Med (2015) 373:224757

Kruse T, Dahl K, Schaffer L, et al

Lipovia GLP-1 Patches are being pushed across social media as the next big breakthrough in effortless weight loss, claiming to mimic the effects of GLP-1 medications like Ozempic and Mounjaro through the skin

The fundamental issue is that the skin barrier prevents the absorption of weight loss compounds at levels that could meaningfully affect appetite or metabolism