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More patients have been diagnosed since the inclusion of lcFAODs in NBS panels, often before development of symptoms and it is debated whether dietary restrictions should be alleviated in certain patient groups [147, 148]

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Beyond technological innovations in drug delivery, addressing the substantial interindividual variability in SFN response is equally crucial

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Unknown long-term profile: While short- and mid-term studies show good tolerability, the long-term safety of chronic Cagrilintide use is still being evaluated in Phase III trials

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