LNP preparation All lipids used in this study were purchased from commercial vendors: DLin-MC3-DMA from Cayman Chemicals, Cholesterol from Sigma-Aldrich and DSPC and PEG2000-DMG from Avanti Polar Lipids
This protection is mainly accomplished by phase II detoxifying enzymes belonging to two antioxidant systems, namely thioredoxin and glutathione systems, which use hydrophilic thiol-containing molecules (thioredoxin and glutathione, respectively), as electron donors to generate conjugated metabolites (Arnr and Holmgren, Phospholipid-hydroperoxide glutathione peroxidase and membrane protection Phospholipid hydroperoxide glutathione peroxidase, glutathione peroxidase 4, or GPx4, is a member of glutathione peroxidases family of selenoproteins, most of which bear a selenocystein as catalytically active amino acid, which confers a more efficient reaction with peroxide substrates (Nauser et al., GPx4 is also peculiar amongst glutathione peroxidases because of its additional regulatory functions
Mortality Two (1%) patients died during treatment (1 patient from myelodysplastic syndrome and 1 due to complications of a bone marrow transplant)
Previous studies also reported that GR plays a key role in heavy metal tolerance by keeping high GSH/GSSG ratios (Schirmer et al., A
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