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Specific gene variants like GLP1R rs6923761 and GIPR rs1800437 affect receptor sensitivity and downstream signaling efficiency, meaning some individuals see rapid, pronounced appetite reduction while others experience more gradual changes

The Jorge study specifically found cardiovascular and kidney benefits in this population, which is encouraging

The paradoxical thing about the evidence so far: the published animal data on Epitalon have predominantly shown no increased cancer incidence, some even report a reduced tumour rate (Anisimov et al., 2003)