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Key genes modulated by GHK-Cu include: Genes encoding growth factors (FGF, VEGF, TGF-) Collagen and extracellular matrix proteins (COL1A1, COL3A1, ELN) Anti-inflammatory and antioxidant enzymes (SOD, catalase) Cell adhesion and communication molecules Collagen & Extracellular Matrix Synthesis Collagen synthesis is fundamental to GHK-Cu's regenerative effects

Figure 1 illustrates the sequential stages of the charcoal rot disease cycle in sesame, from microsclerotial survival in soil and crop debris to root penetration, tissue colonization, symptom development, and return of inoculum to the soil

doi: 10.1111/j.1574-6968.1997.tb10212.x