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Conversely, when GPX8 is silenced, the histamine-induced release of Ca 2+ from the endoplasmic reticulum to mitochondria and cytoplasm is increased (Yoboue et al., 2017)

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Weight of evidence: Overall evidence is Low, some RCTs document benefits for social communication and internalizing symptoms, but findings are inconsistent across age groups and severity levels, and no study integrates redox biomarkers to confirm mechanistic effects

Absorption, systemic exposure, and bioavailability vary greatly depending on the administration route - and these factors determine whether a peptide reaches its target effectively