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Asimismo, fue demostrado que la diferenciacin insulina-positiva de clulas epiteliales pancreticas (AR42J) por la activacin de GLP-1R es mediada por cambios en la expresin de factores de transcripcin smad2 y smad3 y que la accin depende de isoformas endgenas del factor transformante de crecimiento beta (21,22)

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So in the pancreas, we know that it's primarily on the insulin producing cells, and then we also have them in the intestine where they're probably involved in regulating inflammation and really creating a much healthier gut