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JG and IC participated in drafting of the manuscript and revised the manuscript critically

Pain Relief : Over-the-counter pain medication can help manage headaches and pain, providing relief

This work was partially supported by grants from the National Natural Science Foundation of China (82090031, 82090030, and 81521062 to X.-M.L.), the National Key R&D Plan of the Ministry of Science and Technology of China (2016YF051000 to X.-M.L.), Science and Technology Program of Guangdong (2018B030334001 to X.-M.L.), Key Realm R&D Program of Guangdong Province (2019B030335001 to X.-M.L.), Non-Profit Central Research Institute Fund of the Chinese Academy of Medical Sciences (2019PT310023 to X.-M.L.), and CAMS Innovation Fund for Medical Sciences (2019-I2M-5-057 to X.-M.L.), the National Natural Science Foundation of China (81922071 to Y.Z.), the National Key Basic Research Program of China (2019YFA0508800 to Y.Z.), Zhejiang Province Science Fund for Distinguished Young Scholars (LR19H310001 to Y.Z.)

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