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The consequence of its deficiency results in increased stress conditions, which is the basis of the pathophysiology of many organ or tissue-specific diseases such as inflammation, virus infections (HIV), sickle cell anemia, cancer, diabetes, heart attack, stroke, liver disease, cystic fibrosis, Alzheimers, and Parkinsons disease [17,18]

Limited long-term human studies

Additionally, rectal administration can result in higher bioavailability and faster onset of action compared to some other routes, as the medication bypasses the first-pass metabolism in the liver

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