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The EDICT study, employing diabetes medications (GLP-1 receptor agonist, pioglitazone, metformin) that correct the basic underlying pathophysiologic defects present in type 2 diabetes, convincingly demonstrated that combination therapy produces a greater and more durable reduction in HbA1c than the treat-to-fail approach using diabetes medications (sulfonylureas, metformin, insulin) that do not correct the basic metabolic and cellular defects (insulin resistance and beta-cell dysfunction) present in type 2 diabetes patients

The goal is healthier body composition, better metabolic function, and a plan that is monitored with the patients overall health in mind

Subsequently, 60 studies were excluded due to the absence of alcohol-related outcomes, lack of GLP-1RA exposure, or unsuitable study design

PMCID: PMC3309517