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Maintains cellular energy balance by regulating acetyl-CoA levels
In AD mouse models, semaglutide increased the expression of SIRT1 and its downstream target, glucose transporter GLUT4, thereby enhancing glucose uptake and rectifying glycolytic deficits in the hippocampus ( 5.3 Direct neuroprotective and pro-survival pathways In addition to its anti-inflammatory and metabolic effects, semaglutide activates pathways that directly enhance neuronal survival and resilience
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