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The effects of FAT domain inhibition were then compared against the FAK kinase inhibitor, defactinib, which is the most clinically advanced FAK inhibitor in development and currently being investigated in Phase III clinical trials (NCT06072781)

Furthermore, a coherent alteration of the lysine catabolism was recently observed in diurnal metabolic pathways impacted by high-fat diet, suggesting that fructose intake can similarly exacerbate the alteration of amino acid metabolism [60]

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