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Concluding Remarks The overall objective of our mini-review was to highlight the beneficial and detrimental role of ROS that comparatively determine and influence the cyclic waves of spermatogenesis and the species preservation

Limitations and Next Steps: Patients with recent relapses or active MRI lesions were excluded, limiting generalizability Further follow-up on tolebrutinib is needed to evaluate long-term safety and real-world efficacy Additional studies may explore impact on cognitive function and quality of life Main Takeaway The HERCULES trial demonstrates that tolebrutinib has a significantly lower risk of disability for patients with non-relapsing SPMS when compared to placebo, redefining treatment goals for patients and providers alike

Sahebkar A, Reiner , Simental-Menda LE, Ferretti G, Cicero AF

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