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Apolipoprotein E4 impairs neuronal insulin signaling by trapping insulin receptor in the endosomes

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Although fatigue prevalence fluctuates concerning cirrhosis etiology, ranging from 44% in autoimmune liver disease to as high as 80% in primary biliary cholangitis (7), it is noteworthy that this symptom may not necessarily correlate with the severity of underlying liver fibrosis, advanced disease stages, or organ dysfunction

J Assoc Physicians India 2000;48(11):1050-1052