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Human embryonic stem cell-derived MSCs can also treat CTX-induced POF mice, potentially through paracrine mechanisms that involve the secretion of VEGF, IGF-2, and hepatocyte growth factor which help improve ovarian function, reduce granulosa cell apoptosis, and restore fertility [129]
Also, patients should be warned about the danger of taking folic acid in place of Vitamin B12, because the former may prevent anemia but allow progression of subacute combined degeneration
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