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Nevertheless, the overlapping metabolic pathways in two senescence conditions jointly suggested that MOTS-c treatment triggered the reduction of pathways related with glutamate and aspartate in -cells (Fig

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A 2025 University of Virginia study concluded that while GLP-1 drugs significantly reduce body weight and adiposity, they do so "with no clear evidence of cardiorespiratory fitness enhancement"a critical finding given that cardiorespiratory fitness is among the most potent predictors of all-cause and cardiovascular mortality [48]