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Tirzepatide is an imbalanced and biased dual GIP and GLP-1 receptor agonist Text PDF Abstract Tirzepatide (LY3298176) is a dual GIP and GLP-1 receptor agonist under development for the treatment of type 2 diabetes mellitus (T2DM), obesity, and nonalcoholic steatohepatitis

GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) commonly cause headaches during initial weeks or after dose escalation due to altered gastric emptying, hydration changes, and metabolic adjustments

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