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In addition, NAPQI can directly modify the cysteine sulfhydryl group of the cytosolic kelch-like ECH associated protein 1 (Keap1), allowing the separation of nuclear factor erythroid 2-related factor 2 (Nrf2) from Keap1 by deubiquitination

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after the end of the study, 5 (38%) had stable disease (6 weeks after treatment), and the other 8 had disease progression, with the median time to disease progression of 51 days

Unlike most peptides, which bind to a specific GPCR or tyrosine kinase, AOD-9604 acts via several indirect pathways with a predominance of effects on adipocytes (fat cells)