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Alginates (such as Gaviscon) work differently by forming a protective barrier that floats on top of stomach contents, physically preventing reflux

The drug also acts on the hypothalamus, a part of the brain that regulates signaling for many different functions

Subgroup analyses for continuous endpoints in relation to the secondary hypothetical estimand (on treatment with trial product) were performed using a mixed model with treatment by BMI group adjusted for the relevant continuous baseline variable, all nested within visit, and treatment by BMI groups was evaluated at week 52 using on-treatment data

More severe but rare effects include pancreatitis and gallbladder complications, which is why medical supervision during titration matters