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During short-term clinical trials in patients with benign prostatic hyperplasia (BPH) or both BPH and erectile dysfunction, the following gastrointestinal effects occurred in at least 1% of tadalafil-treated patients and more frequently than in placebo-treated patients: dyspepsia (2.4% vs 0.2%) and diarrhea (1.4% vs 1%)

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The number of GLP-1 prescriptions increased from approximately 3,000 to 22,000 per 100,000 commercial members from 2018 to 2023, a more than seven-fold increase

88,109111 The physiology of the ANS and the cardiovascular control have been extensively reviewed elsewhere