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Oral NAD+ does not survive digestion intact

But like most beneficial peptides, plasma concentrations decline sharply with age from roughly 200 ng/mL at age 20 to around 80 ng/mL by age 60

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Factors affecting individual clearance Multiple factors influence how quickly peptides clear from your system: Body composition: Higher body fat may affect distribution and clearance of some compounds Kidney function: Renal clearance is the primary elimination pathway for most peptides Hydration status: Affects urine concentration and potentially detection thresholds Dosage: Higher doses require longer clearance times Frequency of use: Chronic use may result in accumulation Administration route: Injectable, oral, and nasal routes have different pharmacokinetics These factors create significant individual variation