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reducing fat intake to under 30% of calories during the first month markedly improves tolerance in clinical trial participants

Treatment and Dosing With Tirzepatide and Semaglutide Dosing begins low (0.25 mg with semaglutide or 2.5 mg with tirzepatide) and goes up gradually, this is called titration

The reduction in purine levels was associated with increased oxidative stress and endothelial dysfunction, both of which have been implicated in the pathophysiology of both ME/CFS and GWS (Furuhashi, 2020

doi: 10.3390/ijms23084404