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The article says most reported headaches emerge within the first 1 to 2 weeks of starting or during a dose increase

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Lee SG, Ro HS, Hong SP, Kim EH, Sung MH (1996) Production of L-DOPA by thermostable tyrosine phenol-lyase of a thermophilic Symbiobacterium species overexpressed in recombinant Escherichia coli