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Cancer cells produce high levels of endogenous antioxidant enzymes that neutralize FR, seeking to compensate for intracellular ROS levels, and this mechanism facilitates the survival of neoplastic cells [175]

These drugs, beyond their specific effects, elicit also a cellular stress including an unbalance of redox state [7] that is counteracted not only utilizing antioxidant species but also increasing the outcome export by transporters to detoxify the internal environment [8], [9]

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This strategy doesnt lower the clinics price, but it makes treatment more tax-efficient