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Halliwell B, Gutteridge JMC

What is PT-141

Excited to share that the final chapter of my PhD thesis is now published in the Journal of Medicinal Chemistry ( Although reactivity with glutathione is commonly used as a proxy for metabolic liability of covalent drugs, in this work we show that the intrinsic reactivity (electrophilicity) of covalent warheads is not a reliable predictor of their in vivo metabolic susceptibility

83 MylonaP.PawlowskiK.BisselingT