This is due to several factors that differ between the controlled conditions of in vitro studies and the complex biological processes in living organisms, including interactions between different cell types, organ systems, and environmental variables (e.g., gut microbiota or circulation) that can influence how a drug works
While urolithin A may be able to promote better mitochondrial health by supporting mitophagy,7 there currently isnt any research to suggest that the compound could benefit primary or genetic mitochondrial diseases (e.g., Leigh syndrome, Kearns-Sayre syndrome, Leber hereditary optic neuropathy, etc.).16 Some experts suggest that it could be worth investigating whether mitophagy activation could act as a novel strategy to treat these diseases, but that research hasnt been conducted yet.17 18 19 When that happens, well update this information
113,114 Current treatments are only partially effective, and further understanding of the diseases mechanism are needed to develop effective drugs
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