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The underlying mechanism involves the participation of helper T cells (Th) type 2 cells, type 2 innate lymphocytes, helper T follicular cells, eosinophils, mast cells, and marker type 2 mediators, including cytokines IL-4, IL-5, and IL-13 (Ray and Kolls, 2017)

This mechanism initiates the intrinsic apoptosis pathway specifically in senescent cells, while healthy cells maintain different p53 regulation mechanisms and remain unaffected by the peptide administration

(PubMed) Mangiapane E, Pessione A, Pessione E

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