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Rosenstock J, Ferrannini E

Cui L, Huang H, Zhang H, Wang X, Qin X, Tu T, Zhang J, Su X, Yu H, Bai Y, Luo H, Yao B, Wang Y (2022) Recombinant expression of hen egg white lysozyme with the assistance of xylanase fusion partner in Pichia pastoris

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3.1.1 Novel Levodopa Formulations and Delivery 3.1.1.1 Extended-Release Levodopa Efforts to increase levodopas half-life and thereby reduce motor fluctuations and prolong ON-time have started more than 5 decades ago with the introduction of sustained and controlled-release (CR) levodopa formulations [15,16,17], however the evidence base for the efficacy of the first-generation agents has remained slim [14]