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Aliso Viejo, Anaheim, Brea, Buena Park, Costa Mesa, Coto de Caza, Cypress, Dana Point, Fountain Valley, Fullerton, Garden Grove, Huntington Beach, Irvine, La Habra, La Palma, Laguna Beach, Laguna Hills, Laguna Niguel, Laguna Woods, Ladera Ranch, Lake Forest, Los Alamitos, Mission Viejo, Newport Beach, Orange, Placentia, Rancho Santa Margarita, San Clemente, San Juan Capistrano, Santa Ana, Seal Beach, Stanton, Tustin, Villa Park, Westminster, or Yorba Linda

It operates within several pathways, with the mesolimbic pathway being particularly important for the sensation of pleasure and reward

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The top 10 significantly enriched pathways include Glycerophospholipid metabolism, Choline metabolism in cancer, Insulin signaling pathway in cancer, Glycolysis/Gluconeogenesis, Central carbon metabolism in cancer, Alanine, aspartate and glutamate metabolism, Niacin and Niacinamide metabolism, -Alanine metabolism, Insulin resistance, and the AMPK (AMP-activated protein kinase) signaling pathway (Figure 5B)