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Potent Anti-Inflammatory Signaling ARA-290 suppresses pro-inflammatory cytokines, including: TNF- IL-1 IL-6 It also inhibits NF-B signaling, a central driver of chronic inflammation

Both areas are separated by a long ATAAA repetitive stretch, which probably acts as an insulator to separate different epigenetic states such as methylation of the CGIs (Millar et al., 2000)

For TB-500, the status is similar (Investigational New Drug in the US) with very limited human data

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