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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

You may be eligible with a BMI of 30 or higher, or a BMI of 27 or higher with a weight-related health condition

During maintenance, some individuals maintain the same semaglutide or tirzepatide dose that produced their weight loss, while others find that a slightly lower dose sustains their results while reducing potential side effects like nausea or appetite loss