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There are several pharmacological treatments available to augment insulin secretion or reduce peripheral tissue insulin resistance in addition to patients adopting a healthier diet and increased exercise to achieve weight loss, which promotes normoglycaemia and alleviates the disease phenotype

Active Ingredients and How the Extended-Release Tablet Works The Janumet XR ingredients are sitagliptin and metformin hydrochloride extended release

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An alternative mechanism may involve serotonin, either as a result of stimulation of serotonin release from enterochromaffin cells [46], or by reducing serotonin transport via the serotonin transporter (SERT), resulting in increased luminal serotonin