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The Kraus 2014 Nature paper established that NNMT is highly expressed in adipose tissue (especially in obesity) and that NNMT knockdown in adipose protects against diet-induced obesity in mice

Ristoff et al., 2001

Large, highly lipophilic molecule: CoQ10 is a fat-soluble benzoquinone with a long isoprenoid tail, making it extremely hydrophobic and poorly miscible in water-based gastrointestinal fluids