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No obstante, existen otros grupos potencialmente ms sensibles por ejemplo, personas con antecedentes de convulsiones, por lo que, ante cualquier condicin mdica especial o si se est tomando medicacin, lo ms prudente es consultar siempre con un profesional de la salud antes de iniciar su uso

p25 induces the hyperactivation of cyclin-dependent kinase 5 and disrupts GSK3-mediated processes [67]

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However, metformin is not appropriate for people with certain other medical conditions, such as kidney disease, congestive heart failure, metabolic acidosis, and liver issues