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When the cellular antioxidant system undergoes metabolic dysregulation, the accumulation of Fe2+ can mediate the Fenton reaction, resulting in the excessive generation of ROS, particularly hydroxyl radicals

Conclusions and current needs The combination of the amylin analog cagrilintide and the GLP-1R analog semaglutide, called CagriSema, represents a promising novel strategy for treatment of type 2 diabetes and obesity