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40,105 However, given that IGF-1R and insulin receptor have decreased affinity for each others main ligand in comparison to their main ligand, it is likely that insulin and IGF-1 cannot stimulate the anabolic effects of each others receptor activation to the same degree as the main ligands for insulin receptor and IGF-1R at physiological concentrations

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Weeks 1 to 4: 20 units (0.2 mL) once weekly Weeks 5 to 8: 40 units (0.4 mL) once weekly Weeks 9 to 12: 70 units (0.7 mL) once weekly Weeks 13 to 16: 90 units (0.9 mL) once weekly These are unit measurements based on insulin syringe markings

they have also struck deals with retailers, such as Costco, to sell the drugs at a similar discount